GPX4 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comGPX4 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > GPX4(Gene name) > Human

GPX4 (Gene name),

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (Protein name ), GPX4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GPX4;

Protein name:

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(PHGPx);

Alternative:

Glutathione peroxidase 4(GPx-4;GSHPx-4);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Has a tendency to form higher mass oligomers.

Function:

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

Subcellular Location:

Mitochondrion Cytoplasm

Protein Attributes:

Sequence length:

197

Sequence:

50:

100:

150:

197:

PKGKGILGNA | IKWNFTKFLI | DKNGCVVKRY | GPMEEPLVIE | KDLPHYF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2879

SMR:

P36969

UniGene:

Hs.433951

String:

P36969

MIM:

138322

Pfam:

PF00255

STRING:

9606.ENSP00000346103

Uniprot:

P36969

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ELISA Kit for Human PHGPx

Cat.:

E9951m

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Packing:

96T

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ELISA Kit for Human PHGPx

Cat.:

E9951h

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Packing:

96T

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ELISA Kit for Human PHGPx

Cat.:

E9951b

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96T

ELISA Kit for Human PHGPx

Cat.:

E9951m

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96T

ELISA Kit for Human PHGPx

Cat.:

E9951r

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96T

ELISA Kit for Human PHGPx

Cat.:

E9951p

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96T

ELISA Kit for Human PHGPx

Cat.:

E9951r

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96T

CLIA Kit for Human PHGPx

Cat.:

U9951m

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951r

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951r

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951h

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MSDS:

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951m

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MSDS:

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951b

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MSDS:

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Packing:

96T

CLIA Kit for Human PHGPx

Cat.:

U9951p

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96T

Polyclonal Antibody for Human PHGPx

Cat.:

P9951Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human PHGPx

Cat.:

P9951Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PHGPx

Cat.:

P9951Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human PHGPx

Cat.:

P9951Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PHGPx

Cat.:

P9951Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PHGPx

Monoclonal Antibody for Human PHGPx

Protein for Human PHGPx

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase."
Esworthy R.S. , Doan K. , Doroshow J.H. , Chu F.-F.
Gene144:317-318(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Testis.
2.

"Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3."
Kelner M.J. , Montoya M.A.
Biochem. Biophys. Res. Commun.249:53-55(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASN-2
4.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Eye.
tissue: Lung.
tissue: Pancreas.
tissue: Testis.
6.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)."
Scheerer P. , Borchert A. , Krauss N. , Wessner H. , Gerth C. , Hoehne W. , Kuhn H.
Biochemistry46:9041-9049(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 29-197 (ISOFORM CYTOPLASMIC);SUBUNIT;MUTAGENESIS OF SEC-73
8.

"Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4 (GPX4)."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 36-197
9.

"Genetic variations of gpx-4 and male infertility in humans."
Maiorino M. , Bosello V. , Ursini F. , Foresta C. , Garolla A. , Scapin M. , Sztajer H. , Flohe L.
Biol. Reprod.68:1134-1141(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-2 AND THR-120
10.

"Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia."
FORGE Canada Consortium , Smith A.C. , Mears A.J. , Bunker R. , Ahmed A. , MacKenzie M. , Schwartzentruber J.A. , Beaulieu C.L. , Ferretti E. , Majewski J. , Bulman D.E. , Celik F.C. , Boycott K.M. , Graham G.E.
J. Med. Genet.51:470-474(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SMDS

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